Chemical Composition, Cytotoxic and Antibacterial Activity of Essential Oil from Aerial Parts of Salvia tebesana Bunge. Issue 1 (2nd January 2021)

• Record Type: Journal Article
• Authors: Asili, Javad; Tayarani-Najaran, Zahra; Emami, Seyed Ahmad; Iranshahi, Mehrdad; Sahebkar, Amirhossein; Eghbali, Samira
• Is Part Of: Journal of essential oil-bearing plants. Volume 24:Issue 1(2021)
• Page Start: 31
• Page End: 39
• Publication Date: 2021-01-02
• Subjects: Salvia tebesana -- essential oil -- E-nerolidol -- sesquiterpenes -- AlamarBlue®; Essences and essential oils -- Periodicals; Aromatic plants -- Biotechnology -- Periodicals; Oilseed plants -- Biotechnology -- Periodicals; Aromatic plants -- Periodicals; Oilseed plants -- Periodicals; 661.80605
• DOI: 10.1080/0972060X.2021.1886996
• Languages: English
• ISSNs: 0972-060X

Abstract

Abstract: In the present study, chemical composition, antibacterial and cytotoxic activities of the essential oil (EO) from aerial parts of Salvia tebesana were investigated. Fifty-five compounds representing 99.7 % of the total oil composition were identified using gas chromatography-mass spectrometry analysis. The EO was predominated by oxygenated sesquiterpenes and the main constituents were E -nerolidol, α-eudesmol, trans -caryophyllene, caryophyllene oxide, α-pinene, α-epi-cadinol, δ-cadinene, and β-eudesmol, respectively. The cytotoxic effect of the EO on human breast adenocarcinoma, prostate, and melanoma cancer cell lines were examined using AlamarBlue® assay. The EO indicated significant cytotoxic activity against the tested cell lines particularly PC-3. Moreover, the antibacterial evaluation of EO against four bacterial strains indicated a potent activity against Gram-positive bacteria particularly Staphylococcus aureus (minimum inhibitory concentration: 1.4 μg/mL).