Dietary Phytochemicals as a Potential Source for Targeting Cancer Stem Cells. (21st April 2021)

• Record Type: Journal Article
• Authors: Manogaran, Prasath; Umapathy, Devan; Karthikeyan, Manochitra; Venkatachalam, Karthikkumar; Singaravelu, Anbu
• Is Part Of: Cancer investigation. Volume 39:Number 4(2021)
• Page Start: 349
• Page End: 368
• Publication Date: 2021-04-21
• Subjects: Natural products -- cancer stem cells -- cancer -- molecular pathways; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2021.1894569
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: The tumor microenvironment is composed of various types of cells that lead to tumor heterogeneity. In the middle of these populations, cancer stem cells play a vital role in the initiation and progression of cancer cells and are capable of self-renewal and differentiation processes. These cancer stem cells are resistant to conventional therapy such as chemotherapy and radiotherapy. To eradicate the cancer stem cells in the tumor environment, various natural product has been found in recent years. In this review, we have selected some of the natural products based on anticancer potential including targeting cancer cells and cancer stem cells. Further, this review explains the molecular mechanism of action of these natural products in various cancer stem cells. Therefore, targeting a multi-drug resistant cancer stem cell by natural products is a novel method to reduce drug resistance and adverse effect during conventional therapy.