Valganciclovir for cytomegalovirus prevention and treatment. Issue 3 (May 2005)

• Record Type: Journal Article
• Authors: Humar, Atul
• Is Part Of: Therapy. Volume 2:Issue 3(2005)
• Page Start: 333
• Page End: 341
• Publication Date: 2005-05
• Subjects: AIDS -- cytomegalovirus ganciclovir -- organ transplant -- valganciclovir; Therapeutics -- Periodicals; Chemotherapy -- Periodicals; 615.505
• DOI: 10.2217/14750708.2.3.333
• Languages: English
• ISSNs: 1475-0708

Abstract

Cytomegalovirus (CMV) continues to be an important cause of significant disease in various groups of immunocompromised hosts, including organ and hematopoietic stem cell transplant recipients and AIDS patients. Therapeutic and preventative strategies have been used in these patients to improve overall outcomes. Ganciclovir has traditionally been the first-line drug for the treatment and prevention of CMV. Valganciclovir is a prodrug of ganciclovir with enhanced oral bioavailability. Studies have shown that it is effective for the prevention of CMV disease in high-risk (donor seropositive/recipient seronegative) solid-organ transplant recipients. It is also as effective as intravenous ganciclovir for the treatment of CMV retinitis in AIDS patients. The side-effect profile is similar to ganciclovir. Treatment studies in solid-organ transplant recipients, evaluation in pediatric patients, and prevention studies in stem cell recipients are ongoing and will help define the full role of valganciclovir in immunocompromised hosts.