Renal protective capacity of the angiotensin receptor antagonists. Issue 2 (1st November 2004)

• Record Type: Journal Article
• Authors: Smith, Ronald D; Ferrario, Carlos M
• Is Part Of: Therapy. Volume 1:Issue 2(2004)
• Page Start: 331
• Page End: 339
• Publication Date: 2004-11-01
• Subjects: angiotensin II antagonist -- diabetic nephropathy -- hemodynamic and nonhemodynamic mechanisms -- proteinuria -- renal disease progression; Therapeutics -- Periodicals; Chemotherapy -- Periodicals; 615.505
• DOI: 10.2217/14750708.1.2.331
• Languages: English
• ISSNs: 1475-0708

Abstract

Prevention of cardiovascular complications of hypertension has become a hallmark of the therapeutic approach to disease management. Among the many facets of the problem, the association between noninsulin-dependent diabetes mellitus, hypertension and renal function has emerged as a major risk factor for the development of end-stage renal disease requiring dialysis or renal transplantation. This paper reviews the promisory outcomes of long-term clinical trials that demonstrate a renoprotective effect of angiotensin II antagonists on the progression to end-stage renal disease in patients with diabetic nephropathy. The lessons learned from the publication of these trials provide a positive new approach to risk reduction and prevention of loss of renal function in this population.