The Bone Marrow Derived Adult Stem Cells for Dilated Cardiomyopathy (REGENERATE-DCM) trial: study design. (July 2011)

• Record Type: Journal Article
• Authors: Arnous, Samer; Mozid, Abdul; Mathur, Anthony
• Is Part Of: Regenerative medicine. Volume 6:Number 4(2011)
• Page Start: 525
• Page End: 533
• Publication Date: 2011-07
• Subjects: bone marrow -- cardiac repair -- dilated cardiomyopathy -- heart failure -- progenitor cell -- randomized controlled trial -- REGENERATE-DCM trial -- stem cell; Cellular therapy -- Periodicals; Stem cells -- Transplantation -- Periodicals; Degeneration (Pathology) -- Treatment -- Periodicals; Regeneration (Biology) -- Periodicals; 611.018
• DOI: 10.2217/rme.11.29
• Languages: English
• ISSNs: 1746-0751

Abstract

The field of autologous stem/progenitor cell therapy for cardiovascular diseases has moved rapidly from bench to bedside. In particular, a small number of pilot studies have demonstrated the safety and efficacy of this treatment in dilated cardiomyopathy (DCM), but this has to be validated in large randomized trials. Here we introduce the Bone Marrow Derived Adult Stem Cells for Dilated Cardiomyopathy (REGENERATE-DCM) trial, which to our knowledge, is the first randomized, double-blind, placebo-controlled trial worldwide to investigate the role of granulocyte-colony stimulating factor and autologous bone marrow-derived stem/progenitor cells to improve cardiac function in patients with DCM.