Interactions of renin––angiotensin system gene polymorphisms and antihypertensive effect of benazepril in Chinese population. (May 2011)

• Record Type: Journal Article
• Authors: Chen, Qing; Yu, Can-Qing; Tang, Xun; Chen, Da-Fang; Tian, Jun; Cao, Yang; Fan, Wen-Yi; Cao, Wei-Hua; Zhan, Si-Yan; Lv, Jun; Guo, Xiao-Xia; Hu, Yong-Hua; Lee, Li-Ming
• Is Part Of: Pharmacogenomics. Volume 12:Number 5(2011)
• Page Start: 735
• Page End: 743
• Publication Date: 2011-05
• Subjects: angiotensin-converting enzyme inhibitors -- epistasis -- generalized multifactor dimensionality reduction -- hypertension -- pharmacogenetics -- renin––angiotensin system; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs.11.2
• Languages: English
• ISSNs: 1462-2416

Abstract

Aim: Angiotensin-converting enzyme inhibitors are widely used antihypertensive drugs with individual response variation. We studied whether interactions of AGT, AGTR1 and ACE2 gene polymorphisms affect this response.Materials & methods: Our study is based on a 3-year field trial with 1831 hypertensive patients prescribed benazepril. Generalized multifactor dimensionality reduction was used to explore interaction models and logistic regressions were used to confirm them.Results: A two-locus model involving the AGT and ACE2 genes was found in males, the sensitive genotypes showed an odds ratio (OR) of 1.9 (95% CI: 1.3––2.8) when compared with nonsensitive genotypes. Two AGT––AGTR1 models were found in females, with an OR of 3.5 (95% CI: 2.0––5.9) and 3.1 (95% CI: 1.8––5.3).Conclusion: Gender-specific gene––gene interactions of the AGT, AGTR1 and ACE2 genes were associated with individual variation of response to benazepril. Further studies are needed to confirm this finding. Original submitted 1 November 2010; Revision submitted 10 January 2011