Efficacy of clobazam monotherapy in three cases of symptomatic localization-related epilepsy in children. Issue 4 (July 2009)

• Record Type: Journal Article
• Authors: Iwasaki, Toshiyuki; Nonoda, Yutaka; Takei, Kenji; Hosoda, Nozomi; Ishii, Masahiro
• Is Part Of: Therapy. Volume 6:Issue 4(2008)
• Page Start: 589
• Page End: 593
• Publication Date: 2009-07
• Subjects: children -- clobazam -- electroencephalogram -- localization-related epilepsy -- monotherapy -- N-desmethyl clobazam; Therapeutics -- Periodicals; Chemotherapy -- Periodicals; 615.505
• DOI: 10.2217/thy.09.34
• Languages: English
• ISSNs: 1475-0708

Abstract

Clobazam is approved in many countries as an additional antiepileptic drug for the management of intractable epilepsy. However, a number of reports have also described its use as first-line therapy in this indication. In this article, we describe three cases involving children (aged 2––12 years) with symptomatic localization-related and intractable epilepsy who responded to low dosage (0.2––0.4 mg/kg/day) clobazam monotherapy. For periods of 3.1––4.4 years, the treatment was well-tolerated and improved electroencephalogram findings with complete disappearance of clinical convulsions. Thus, low-dose clobazam appears to be a useful treatment option in these difficult-to-manage cases of intractable epilepsy.