Atopic dermatitis: a review of recent advances in the field. Issue 6 (December 2008)

• Record Type: Journal Article
• Authors: Lam, Joseph; Friedlander, Sheila F
• Is Part Of: Pediatric health. Volume 2:Issue 6(2008)
• Page Start: 733
• Page End: 747
• Publication Date: 2008-12
• Subjects: atopic dermatitis -- atopy -- eczema -- management strategies -- topical calcineurin inhibitors -- topical steroids; Pediatrics -- Periodicals; 618.920005
• DOI: 10.2217/17455111.2.6.733
• Languages: English
• ISSNs: 1745-5111

Abstract

Atopic dermatitis is increasing in prevalence and currently affects 15––30% of children in urban areas. Immune dysregulation and an impaired epidermal barrier are important factors in the pathogenesis of this disease. Pruritus and a chronic relapsing remitting course are hallmarks of the disorder, and sleep disturbance can occur in both the patient and family. Preventive interventions include exclusive breastfeeding in the first 4 months of life and withholding solid foods for 6 months. The avoidance of irritants and the use of emollients decrease flares. Topical corticosteroids remain the mainstay of therapy, and should be judiciously utilized. Excessive and inappropriate use must be avoided, as well as ''steroid phobia''. The topical calcineurin inhibitors can be useful adjuncts. Systemic therapies are available for severe disease, but carry risks of adverse effects.