T04. Clinical utility of electromagnetic source imaging in the Danish presurgical epilepsy evaluation. (May 2018)

• Record Type: Journal Article
• Authors: Duez, Lene; Tankisi, Hatice; Henriksen, Otto M.; Hansen, Peter O.; Sabers, Anne; Pinborg, Lars; Fabricius, Martin; Rásonyi, György; Rubboli, Guido; Pedersen, Birthe; Leffers, Anne-Mette; Uldall, Peter; Jespersen, Bo; Brennum, Jannick; Fuglsang-Frederiksen, Anders; Beniczky, Sandor
• Is Part Of: Clinical neurophysiology. Volume 129(2018)Supplement 1
• Page Start: e2
• Publication Date: 2018-05
• Subjects: Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2018.04.005
• Languages: English
• ISSNs: 1388-2457

Abstract

Abstract : Introduction: The greatest challenge in epilepsy surgery lies in the presurgical evaluation. On their own, none of the diagnostic methods can identify the epileptogenic zone. Therefore, a multimodal approach is used. Over the last decades, advances in recording techniques and in signal analysis made it possible to estimate the source of the epileptiform discharges recorded by electroencephalography (EEG source imaging: ESI) and magnetoencephalography (MEG source imaging: MSI). This prospective study investigates the role of electromagnetic source imaging (EMSI) as a non-invasive tool to guide the multidisciplinary epilepsy surgery team. Methods: MEG (306 channels) and simultaneous high-density EEG was recorded in 85 consecutive patients with refractory focal epilepsy, referred for conventional non-invasive presurgical evaluation. EMSI, comprising of electric, magnetic source imaging and analysis of combined MEG-EEG datasets, using commercially available software (BESA and CURRY) was used. The Danish epilepsy surgery team evaluated the patients first blinded to EMSI and then including the data from EMSI. At both sessions the multidisciplinary team (MDT) determined the presumed localisation of the epileptogenic zone and decided on location of surgery, intracranial registration (ICR) placement, or not offering epilepsy surgery. The clinical utility of EMSI was defined as the proportion of patients in whom EMSI changed the decision of the MDT. A change was defined useful as follows: (a) change from stop to ICR: the ICR localized the source; (b) change in implantation strategy: the electrode(s) implanted based on the EMSI identified the source; and (c) change from implantation to operation: the patient became seizure-free. Results: The impact of EMSI on patient management-plan was assessed in 85 patients (50 men) in whom EMSI was part of the decision-making process. The age of these patients was between 10 and 70 years (median: 32 years). Thirty-eight patients were MRI negative; in the remaining patients, there were discordance between MRI and data from long-term video-EEG monitoring (semiology and EEG). EMSI changed the management plan in 28/85 patients (33%). For 16.5% (14/85) of the patients the ICR plan changed (additional structures were implanted). For 7% (6/85) of the patients, in whom neither operation nor ICR was suggested, after discussing the EMSI results, ICR was offered. For 9.4% (8/85) of the patients ICR was suggested prior to EMSI; after EMSI these patients skipped ICR and went directly to operation. Finally, for one patient it was decided not to offer operation, after discussing the EMSI. At one-year follow-up 80% (16/20) of these changes proved to be useful, meaning that the EMSI changes located the seizure onset zone, irritative zone or the patient became seizure free. Conclusion: Electromagnetic source imagening provides clinically relevant information that supplements the decision-making process in presurgery evaluation for epilepsy surgery.