Strategies and advances in nanomedicine for targeted siRNA delivery. (June 2011)

• Record Type: Journal Article
• Authors: Nimesh, Surendra; Gupta, Nidhi; Chandra, Ramesh
• Is Part Of: Nanomedicine. Volume 6:Number 4(2011)
• Page Start: 729
• Page End: 746
• Publication Date: 2011-06
• Subjects: chitosan -- nanoparticles -- polycationic -- polyethylenimine -- siRNA; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm.11.15
• Languages: English
• ISSNs: 1743-5889

Abstract

SiRNA are a rapidly emerging class of new therapeutic molecules for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability in physiological conditions limits its therapeutic potential, hence a need to develop a delivery system that can protect and efficiently transport siRNA to the target cells has arisen. Nanoparticles have been proposed as suitable delivery vectors with reduced cytotoxicity and enhanced efficacy. These delivery vectors form condensed complexes with siRNA which, in turn, provides protection to siRNA against enzymatic degradation and further leads to tissue and cellular targeting. Nanoparticles derived from polymers, such as chitosan and polyethylenimine have found numerous applications owing to ease of manipulation, high stability, low cost and high gene carrying capability. This article focuses on various aspects of nanomedicine based siRNA delivery with emphasis on targeted delivery to tumors.