Hyaluronan- and heparin-reduced silver nanoparticles with antimicrobial properties. (June 2009)

• Record Type: Journal Article
• Authors: Kemp, Melissa M; Kumar, Ashavani; Clement, Dylan; Ajayan, Pulickel; Mousa, Shaker; Linhardt, Robert J
• Is Part Of: Nanomedicine. Volume 4:Number 4(2009)
• Page Start: 421
• Page End: 429
• Publication Date: 2009-06
• Subjects: antimicrobial -- Escherichia coli -- silver heparin nanoparticles -- silver hyaluronan nanoparticles -- silver nanoparticles -- Staphylococcus aureus; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm.09.24
• Languages: English
• ISSNs: 1743-5889

Abstract

Aims: Silver nanoparticles exhibit unique antibacterial properties that make these ideal candidates for biological and medical applications. We utilized a clean method involving a single synthetic step to prepare silver nanoparticles that exhibit antimicrobial activity. Materials & methods: These nanoparticles were prepared by reducing silver nitrate with diaminopyridinylated heparin (DAPHP) and hyaluronan (HA) polysaccharides and tested for their efficacy in inhibiting microbial growth. Results & discussion: The resulting silver nanoparticles exhibit potent antimicrobial activity against Staphylococcus aureus and modest activity against Escherichia coli . Silver––HA showed greater antimicrobial activity than silver––DAPHP, while silver––glucose nanoparticles exhibited very weak antimicrobial activity. Neither HA nor DAPHP showed activity against S. aureus or E. coli .Conclusion: These results suggest that DAPHP and HA silver nanoparticles have potential in antimicrobial therapeutic applications.