Surface-active liposomes for targeted cancer therapy. (October 2007)

• Record Type: Journal Article
• Authors: Sofou, Stavroula
• Is Part Of: Nanomedicine. Volume 2:Number 5(2007)
• Page Start: 711
• Page End: 724
• Publication Date: 2007-10
• Subjects: heat responsive liposomes -- immunoliposomes -- liposome cancer therapy -- long circulating liposomes -- PEGylated liposomes -- pH-sensitive liposomes -- responsive liposomes -- targeted liposomes -- temperature responsive liposomes; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/17435889.2.5.711
• Languages: English
• ISSNs: 1743-5889

Abstract

An overview of liposome-based drug-delivery carriers to cancer cells is presented. Properties related to interfacial interactions between liposomes and the biological milieu that determine the fate of liposomes in vivo are discussed. Original approaches to improve specificity for the target and to control the structural responsiveness of liposomes, depending on their immediate environment, with the aim of enhancing the delivered therapeutic doses, are summarized. This review is not exhaustive on research examples of liposomes as carriers for cancer therapy but, rather, aims to describe major directions of designs and strategies over recent years. The current therapeutic trends that exhibit increasingly higher complexity in structures and responses are also discussed.