Concomitant use of clopidogrel and proton-pump inhibitor: a reality check. (April 2010)

• Record Type: Journal Article
• Authors: Banerjee, Subhash; Zankar, Ahmad; Weideman, Rick; Little, Bertis; Brilakis, Emmanouil S
• Is Part Of: Interventional cardiology. Volume 2:Number 2(2010)
• Page Start: 121
• Page End: 125
• Publication Date: 2010-04
• Subjects: cardiovascular outcome -- clopidogrel -- proton-pump inhibitor; Cardiology -- Periodicals; Coronary heart disease -- Treatment -- Periodicals; 616.1205
• DOI: 10.2217/ica.10.12
• Languages: English
• ISSNs: 1755-5310

Abstract

There are emerging reports supporting the fact that proton-pump inhibitors competitively inhibit the metabolism of clopidogrel to its active metabolite and diminish its clinical efficacy, especially in patients on long-term dual antiplatelet therapy. In this article, we examine the current evidence and provide interpretation of the results along with practical recommendations for healthcare providers.