Cognitive disorders and brain MRI correlations in primary Sjöögren''s syndrome: unlocking the secret of cognitive symptoms. (February 2011)

• Record Type: Journal Article
• Authors: Segal, Barbara M; Mueller, Bryon A
• Is Part Of: International journal of clinical rheumatology. Volume 6:Number 1(2011)
• Page Start: 35
• Page End: 45
• Publication Date: 2011-02
• Subjects: brain MRI -- cognitive disorders -- mood -- Sjöögren''s syndrome; Rheumatology -- Periodicals; 616.723005
• DOI: 10.2217/ijr.10.99
• Languages: English
• ISSNs: 1758-4272

Abstract

Little is known concerning the mechanisms of cognitive impairment in primary Sjöögren''s syndrome. However, recent technological advances have made detailed brain imaging studies possible, which have the potential to estimate more precisely the prevalence of CNS lesions in primary Sjöögren''s syndrome and to provide information on the severity and mechanisms of CNS tissue damage. Novel neuroimaging protocols can provide a window into cerebral organization that is not accessible with conventional imaging methods. Investigation of cognitive function with state of the art high-resolution structural and functional brain MRI could illuminate the mechanisms contributing to subtle cognitive dysfunction and guide the development of specific therapeutic approaches.