Minority drug-resistant HIV-1 variants: transmission and response to antiretroviral therapy. Issue 1 (January 2009)

• Record Type: Journal Article
• Authors: Masquelier, Bernard
• Is Part Of: HIV therapy. Volume 3:Issue 1(2009)
• Page Start: 55
• Page End: 61
• Publication Date: 2009-01
• Subjects: antiretroviral therapy -- genotypic analysis -- HIV-1 transmission -- HIV drug resistance -- mutations -- PCR -- ultra-deep sequencing; HIV (Viruses) -- Treatment -- Periodicals; HIV (Viruses) -- Research -- Periodicals; 616.979206
• DOI: 10.2217/17584310.3.1.55
• Languages: English
• ISSNs: 1758-4310

Abstract

The transmission of HIV-1 variants with resistance to antiretroviral therapy can impair response to first-line antiretroviral therapy. The current genotypic tests used for surveillance of HIV-1 resistance and routine management of antiretroviral therapy have a limit of sensitivity of approximately 20% of the bulk viral population for the detection of minority variants. Ultrasensitive genotypic techniques have been developed and are able to increase the detection of minority-resistant viruses in a significant proportion of antiretroviral-naive patients. De novo production and transmission of minority variants are discussed. Discordant results have been reported considering the clinical relevance of minority resistant variants and their impact on first-line therapy, which could be due to treatment regimens and the duration of infection.