Axonal microRNAs: localization, function and regulatory mechanism during axon development. (6th January 2017)

• Record Type: Journal Article
• Authors: Wang, Bin; Bao, Lan
• Is Part Of: Journal of molecular cell biology. Volume 9:Number 2(2017:Apr.)
• Page Start: 82
• Page End: 90
• Publication Date: 2017-01-06
• Subjects: axonal miRNA -- compartmentalized culture -- axon development -- RNA-binding protein; Molecular biology -- Periodicals; 571.605
• DOI: 10.1093/jmcb/mjw050
• Languages: English
• ISSNs: 1674-2788

Abstract

Abstract: Subcellular localization and translation of messenger RNAs are essential for the regulation of neuronal development and synaptic function. As post-transcriptional regulators, microRNAs (miRNAs) have been emerging as central players in the development and maturation of the nervous system. Recent discoveries reveal the critical functions of miRNAs in the axon of neurons via multiple pathways of molecular regulation. Here, we introduce methods for isolating axonal miRNAs and review recent findings on the localization and function as well as regulatory mechanism of axonal miRNAs during axon development.