Large Outbreak of Hepatitis C Virus Associated With Drug Diversion by a Healthcare Technician. (14th May 2018)

• Record Type: Journal Article
• Authors: Alroy-Preis, Sharon; Daly, Elizabeth R; Adamski, Christine; Dionne-Odom, Jodie; Talbot, Elizabeth A; Gao, Fengxiang; Cavallo, Steffany J; Hansen, Katrina; Mahoney, Jennifer C; Metcalf, Erin; Loring, Carol; Bean, Christine; Drobeniuc, Jan; Xia, Guo-Liang; Kamili, Saleem; Montero, José T
• Is Part Of: Clinical infectious diseases. Volume 67:Number 6(2018)
• Page Start: 845
• Page End: 853
• Publication Date: 2018-05-14
• Subjects: hepatitis C -- outbreak -- healthcare-associated infections -- drug diversion -- HCV quasispecies; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciy193
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Background: In May 2012, the New Hampshire (NH) Division of Public Health Services (DPHS) was notified of 4 persons with newly diagnosed hepatitis C virus (HCV) infection at hospital X. Initial investigation suggested a common link to the hospital cardiac catheterization laboratory (CCL) because the infected persons included 3 CCL patients and a CCL technician. NH DPHS initiated an investigation to determine the source and control the outbreak. Methods: NH DPHS conducted site visits, case patient and employee interviews, medical record and medication use review, and employee and patient HCV testing using enzyme immunoassay for anti-HCV, reverse-transcription polymerase chain reaction for HCV RNA, nonstructural 5B (NS5B) and hypervariable region 1 (HVR1) sequencing, and quasispecies analysis. Results: HCV HVR1 analysis of the first 4 cases confirmed a common source of infection. HCV testing identified 32 of 1074 CCL patients infected with the outbreak strain, including 3 patients coinfected with >1 HCV strain. The epidemiologic investigation revealed evidence of drug diversion by the HCV-infected technician, evidenced by gaps in controlled medication control, higher fentanyl use during procedures for confirmed cases, and building card key access records documenting the presence of the technician during days when transmission occurred. The employee's status as a traveling technician led to a multistate investigation, which identified additional cases at prior employment sites. Conclusions: This is the largest laboratory-confirmed drug diversion–associated HCV outbreak published to date. Recommendations to reduce drug diversion risk and to conduct outbreak investigations are provided. Abstract : An outbreak of hepatitis C virus at a hospital was associated with drug diversion by a healthcare worker. Healthcare facilities and public health must work together to create proactive, comprehensive approaches to prevent, detect, and respond to drug diversion events.