Genome‐scale model of C. autoethanogenum reveals optimal bioprocess conditions for high‐value chemical production from carbon monoxide. Issue 2 (20th June 2019)

• Record Type: Journal Article
• Authors: Norman, Rupert O.J.; Millat, Thomas; Schatschneider, Sarah; Henstra, Anne M.; Breitkopf, Ronja; Pander, Bart; Annan, Florence J.; Piatek, Pawel; Hartman, Hassan B.; Poolman, Mark G.; Fell, David A.; Winzer, Klaus; Minton, Nigel P.; Hodgman, Charlie
• Is Part Of: Engineering biology. Volume 3:Issue 2(2019)
• Page Start: 32
• Page End: 40
• Publication Date: 2019-06-20
• Subjects: renewable materials -- genomics -- organic compounds -- microorganisms -- hydrogen production -- fermentation -- biotechnology; optimal bioprocess conditions -- high‐value chemical production -- carbon monoxide -- clostridium autoethanogenum -- industrial microbe -- high‐value platform chemicals -- experimentally parameterised genome‐scale model -- noncarbon‐limited conditions -- hydrogen production -- C. autoethanogenum -- 2, 3‐butanediol -- 2, 3‐BD production -- thermodynamic constraints; Bioengineering -- Periodicals; Bioengineering; Periodicals; 660.605
• DOI: 10.1049/enb.2018.5003
• Languages: English
• ISSNs: 2398-6182

Abstract

Abstract : Clostridium autoethanogenum is an industrial microbe used for the commercial‐scale production of ethanol from carbon monoxide. While significant progress has been made in the attempted diversification of this bioprocess, further improvements are desirable, particularly in the formation of the high‐value platform chemicals such as 2, 3‐butanediol (2, 3‐BD). A new, experimentally parameterised genome‐scale model of C. autoethanogenum predicts dramatically increased 2, 3‐BD production under non‐carbon‐limited conditions when thermodynamic constraints on hydrogen production are considered.