Histologic retrieval rate of a newly designed side‐bevelled 20G needle for EUS‐guided tissue acquisition of solid pancreatic lesions. Issue 1 (1st February 2019)

• Record Type: Journal Article
• Authors: Armellini, Elia; Manfrin, Erminia; Trisolini, Elena; Andorno, Silvano; Ballarè, Marco; Bernardoni, Laura; Boldorini, Renzo Luciano; Gabbrielli, Armando; Frulloni, Luca; Larghi, Alberto; Occhipinti, Pietro; Scarpa, Aldo; Crinò, Stefano Francesco
• Is Part Of: United European Gastroenterology journal. Volume 7:Issue 1(2019)
• Page Start: 96
• Page End: 104
• Publication Date: 2019-02-01
• Subjects: Endosonography -- endoscopic ultrasound-guided tissue acquisition -- fine-needle biopsy (FNB) -- pancreatic cancer -- 20G ProCore® -- solid pancreatic neoplasm; Gastroenterology -- Periodicals; Periodicals; 616.33005
• DOI: 10.1177/2050640618804443
• Languages: English
• ISSNs: 2050-6406

Abstract

Abstract : Background: Innovative approaches to improve diagnostic yield of endoscopic ultrasound‐guided tissue acquisition (EUS‐TA) have focused on needle design with development of fine‐needle biopsy (FNB) needles with microcore‐acquisition technology. Recently, a 20‐gauge (20G) antegrade‐cutting‐side‐bevelled biopsy needle (ProCore®) was developed for EUS‐TA, but data about its diagnostic performance and histological capability are scant. Objectives: We assessed the diagnostic performance and histologic retrieval rate of a new 20G antegrade‐cutting‐side‐bevelled biopsy needle compared with a 22G reverse‐side‐bevelled needle for EUS sampling of solid pancreatic lesions. Patients and methods: A retrospective analysis of 238 consecutively collected patients who underwent EUS‐TA using a 20G or a 22G ProCore® needle, without rapid on‐site evaluation (ROSE), was conducted at two centres. Sensitivity, specificity, positive predictive value and negative predictive value were calculated. Histologic tissue retrieval was evaluated applying a scoring system for each case. Results: Sensitivity and specificity were estimated as 98.4–100% in the 20G‐, and 94.9–100% in the 22G‐needle groups, respectively ( p > 0.99). The 20G procured more histologic‐grade tissues (92.6% vs 49.5%, p < 0.0001) achieved by a lower number of passes (2.64 vs 3.44, p < 0.0001) compared to the 22G. Conclusions: Both side‐bevelled FNB needles achieved a high diagnostic sensitivity. The 20G‐side‐bevelled needle obtained a significantly higher microcore retrieval rate.