Colonic motility in ulcerative colitis. Issue 6 (1st December 2014)

• Record Type: Journal Article
• Authors: Bassotti, Gabrio; Antonelli, Elisabetta; Villanacci, Vincenzo; Baldoni, Monia; Dore, Maria Pina
• Is Part Of: United European Gastroenterology journal. Volume 2:Issue 6(2014:Dec.)
• Page Start: 457
• Page End: 462
• Publication Date: 2014-12-01
• Subjects: Colon -- enteric nervous system -- inflammation -- manometry -- motility -- myenteric plexus -- ulcerative colitis; Gastroenterology -- Periodicals; Periodicals; 616.33005
• DOI: 10.1177/2050640614548096
• Languages: English
• ISSNs: 2050-6406

Abstract

Abstract : Background: Inflammatory conditions affecting the gut may cause motility disturbances, and ulcerative colitis – one of the main disorders among the inflammatory bowel diseases – may display abnormal colonic motility. Aim: To review the abnormalities of the large bowel in ulcerative colitis, by considering the motility, laboratory (in vitro) and pathological studies dealing with this topic. Methods: A comprehensive online search of Medline and the Science Citation Index was carried out. Results: Patients with ulcerative colitis frequently display colonic motor abnormalities, including lack of contractility, an increase of propulsive contractile waves, an excessive production of nitric oxide, vasoactive intestinal polypeptide nerves, interleukin 1 beta, neurotensin, tachykinins levels and the weaker action of substance P, likely related to a neuromuscular dysfunction due to the inflammatory process. Conclusions: A better understanding of the pathophysiological grounds of altered colonic motility in ulcerative colitis may lead to a more in‐depth knowledge of the accompanying symptoms and to better and more targeted therapeutic approaches.