Endoscopic ultrasound‐guided fine needle aspiration of pancreatic lesions with 22 versus 25 Gauge needles: A meta‐analysis. Issue 6 (1st October 2017)

• Record Type: Journal Article
• Authors: Facciorusso, Antonio; Stasi, Elisa; Di Maso, Marianna; Serviddio, Gaetano; Ali Hussein, Mohammed Salah; Muscatiello, Nicola
• Is Part Of: United European Gastroenterology journal. Volume 5:Issue 6(2017)
• Page Start: 846
• Page End: 853
• Publication Date: 2017-10-01
• Subjects: EUS -- FNA -- pancreas -- sensitivity -- specificity; Gastroenterology -- Periodicals; Periodicals; 616.33005
• DOI: 10.1177/2050640616680972
• Languages: English
• ISSNs: 2050-6406

Abstract

Abstract : Background: Robust data in favour of a clear superiority of 22 versus 25 Gauge needles for endoscopic ultrasound‐guided fine needle aspiration are still lacking. Objective: We aimed to compare the diagnostic sensitivity, specificity and safety of these two needles for endoscopic ultrasound‐guided fine needle aspiration of solid pancreatic lesions. Methods: A computerized bibliographic search was restricted to randomized controlled trials only. Pooled effects were calculated using a random‐effects model and expressed in terms of risk ratio and 95% confidence interval. Results: We analysed seven trials with 689 patients and 732 lesions (295 sampled with 22 Gauge needle, 309 with 25 Gauge needle, and 128 with both needles). A non‐significant superiority of 25 Gauge in terms of pooled sensitivity (risk ratio: 0.93, 0.91–0.95 versus 0.89, 0.85–0.94 of 22 Gauge needle; p = 0.13) and no difference in terms of specificity (1.00, 0.98–1.00 in both groups; p = 0.85) were observed. Sample adequacy was similar between the two devices (risk ratio: 1.03, 0.99–1.06; p = 0.15). Very few adverse events were observed and did not impact on patient outcomes. Conclusion: Our meta‐analysis reveals non‐superiority of 25 Gauge over 22 Gauge; hence no definitive recommendations over the use of one particular device can be made.