Lessons from a Minimal Genome: What Are the Essential Organizing Principles of a Cell Built from Scratch?. (8th August 2019)

• Record Type: Journal Article
• Authors: Tarnopol, Rebecca L.; Bowden, Sierra; Hinkle, Kevin; Balakrishnan, Krithika; Nishii, Akira; Kaczmarek, Caleb J.; Pawloski, Tara; Vecchiarelli, Anthony G.
• Is Part Of: Chembiochem. Volume 20:Number 20(2019)
• Page Start: 2535
• Page End: 2545
• Publication Date: 2019-08-08
• Subjects: bottom-up biology -- minimal genome -- self-organization -- synthetic biology -- synthetic cell; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201900249
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract: One of the primary challenges facing synthetic biology is reconstituting a living system from its component parts. A particularly difficult landmark is reconstituting a self‐organizing system that can undergo autonomous chromosome compaction, segregation, and cell division. Here, we discuss how the syn3.0 minimal genome can inform us of the core self‐organizing principles of a living cell and how these self‐organizing processes can be built from the bottom up. The review underscores the importance of fundamental biology in rebuilding life from its molecular constituents. Abstract : A primary challenge in synthetic biology is reconstituting self‐organizing systems that can undergo autonomous chromosome compaction, segregation, and cell division. Here, we discuss how the syn3.0 minimal genome sheds light on the core self‐organizing principles of living cells and how these self‐organizing processes can be built from the bottom up.