Volume change in infrapatellar fat pad is associated not with obesity but with cartilage degeneration. Issue 3 (3rd January 2019)

• Record Type: Journal Article
• Authors: Masaki, Tadashi; Takahashi, Kenji; Hashimoto, Sanshiro; Ikuta, Futoshi; Watanabe, Atsuya; Kiuchi, Shinji; Okuaki, Tomoyuki; Mochizuki, Yusuke; Takai, Shinro
• Is Part Of: Journal of orthopaedic research. Volume 37:Issue 3(2019)
• Page Start: 593
• Page End: 600
• Publication Date: 2019-01-03
• Subjects: knee -- MRI -- fat pad -- cartilage degeneration -- obesity; Orthopedics -- Periodicals; Musculoskeletal system -- Periodicals; 616.7
• DOI: 10.1002/jor.24201
• Languages: English
• ISSNs: 0736-0266

Abstract

ABSTRACT: Infrapatellar fat pad has been implicated in knee osteoarthritis. We examined whether infrapatellar fat pad volume is associated with quantitative cartilage changes using magnetic resonance imaging T1ρ mapping. Fifty‐eight knees of knee pain patients (19 men, 39 women, mean age 57.0 [range 29–85] years) who were conservatively managed and had >1 T1ρ mapping images taken over time were evaluated. We used three slices from the medial femoral and tibial cartilage; areas showing T1ρ values <130 ms and >50 ms were designated as having cartilage degeneration. Cases were categorized into three groups: Improvement, No Change, and Deterioration. Fat‐suppressed T2‐weighted sagittal magnetic resonance images were used for measuring infrapatellar fat pad volume. Percent change in infrapatellar fat pad volume was −5.01 ± 5.66%, −2.06 ± 4.92%, and 0.05 ± 6.09% in the Improvement ( n = 22), No Change ( n = 22), and Deterioration ( n = 14) groups, respectively, demonstrating significantly reduced infrapatellar fat pad volume in the Improvement group ( p < 0.05). Multivariate regression analyses revealed that the percent change in infrapatellar fat pad volume significantly affected T1ρ change category independent of age, sex, follow‐up period, baseline infrapatellar fat pad volume, and Kellgren‐Lawrence grade. Infrapatellar fat pad volume and obesity or body weight change showed no correlation. Infrapatellar fat pad volume was reduced in patients with improved quantitative cartilage assessment on magnetic resonance imaging T1ρ mapping. This is the first study demonstrating associations between quantitative cartilage changes and infrapatellar fat pad morphological changes, suggesting a detrimental role of infrapatellar fat pad volume in articular cartilage degeneration. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res