Polyethylene‐Glycol‐ (PEG‐400) Mediated Environmentally Benign Protocol for the Synthesis of Pyrrolo[1, 2‐a]quinoxalines from Benzyl Amines at Room Temperature. Issue 38 (18th October 2019)

• Record Type: Journal Article
• Authors: Patil, Bhausaheb N.; Lade, Jatin J.; Pardeshi, Sachin D.; Patil, Prashant; Chaskar, Atul C.
• Is Part Of: ChemistrySelect. Volume 4:Issue 38(2019)
• Page Start: 11362
• Page End: 11366
• Publication Date: 2019-10-18
• Subjects: Oxidation PEG-400 Pyrrolo[1, 2-a]quinoxalines Recyclable green solvent Synthetic Methods; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201902656
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A metal‐free, adorable, cascade protocol for the synthesis of pyrrolo[1, 2‐ a ]quinoxalines at room temperature using benzylamine derivatives and 1‐(2‐aminoaryl)pyrrole has been performed. This synthetic protocol involves oxidation of benzylamine derivatives into respective aldehydes followed by condensation with 1‐(2‐aminoaryl)pyrrole in PEG‐400 as a green and reusable solvent using K2 S2 O8 as an oxidant. The transition metal free as well as ligand free synthesis along with broad substrate scope, wide functional group tolerance and good to excellent yield of products makes it environmentally and economically viable. Abstract : Room temperature synthesis of biologically active pyrrolo[1, 2‐ a ]quinoxaline using K2 S2 O8 as an oxidant in PEG‐400 as a green and reusable solvent has been reported. The method offers advantages such as use of inexpensive reagents, non‐hazardous solvent, ambient temperature synthesis and good to excellent yield of products.