Reinvestigating the acyl cyclization to the precursor of diptoindonesin G. (13th April 2021)

• Record Type: Journal Article
• Authors: Li, Nan-Sheng; Greene, Geoffrey L.
• Is Part Of: Tetrahedron letters. Volume 69(2021)
• Publication Date: 2021-04-13
• Subjects: Diptoindonesin G -- Precursor of diptoindonesin G -- Acyl cyclization -- Trifluoroacetic anhydride -- TFAA -- Breast cancer; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2021.152980
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Reinvestigating the acyl cyclization to the precursor of diptoindonesin G. Reinvestigating the chemical synthesis of diptoindonesin G. Reinvestigation the intramolecular Friedel-Crafts acylation catalyzed by TFAA. Abstract: We reinvestigated the synthesis of the precursor of diptoindonesin G (2 ) by the intramolecular acyl cyclization of compound 1 or compound 3 in the presence of trifluoroacetic anhydride (TFAA) [1, 2 ]. Although the reaction of 3 with TFAA generated 2 smoothly as reported, the reaction of 1 with TFAA failed to afford 2, and compound 1 was partially decomposed under the reaction conditions tested.