Performance of 18F-FDG, 11C-Methionine, and 18F-FET PET for Glioma Grading: A Meta-analysis. (November 2019)

• Record Type: Journal Article
• Authors: Katsanos, Aristeidis H.; Alexiou, George A.; Fotopoulos, Andreas D.; Jabbour, Pascal; Kyritsis, Athanasios P.; Sioka, Chrissa
• Is Part Of: Clinical nuclear medicine. Volume 44:Number 11(2019)
• Publication Date: 2019-11
• Subjects: FDG -- FET -- glioma -- grade -- MET -- PET; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000002654
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Purpose: Gliomas constitute the most frequent primary brain tumors. Glioblastoma, the most common and malignant glioma in adults, has dismal prognosis with any current therapy. On the other hand, low-grade gliomas, the second most common type of gliomas, are potentially curative with appropriate treatment. Methods: We conducted a meta-analysis to assess the performance of PET tracers with the best available evidence, namely, fluorodeoxyglucose (FDG), 11 C-methionine (MET), and 18 F-fluoroethyltyrosine (FET), in differentiating low- from high-grade gliomas. Results: Twenty-three studies with a total of 994 participants were included in this meta-analysis. The pooled sensitivities of both MET PET and FET PET were found to be significantly higher than of FDG PET (94%, 88%, and 63% respectively, P < 0.001). The pooled specificity of FDG PET was found to be significantly greater compared with both MET PET and FET PET (89%, 55%, and 57%, respectively; P = 0.002). Fluorodeoxyglucose PET was superior in terms of higher positive likelihood ratio values compared with both FET PET and MET PET. Conclusions: This meta-analysis indicated that both MET and FET were superior to FDG in terms of sensitivity for identifying glioma grade. Abstract : Supplemental digital content is available in the text.