Endothelial Targets in Stroke: Translating Animal Models to Human. Issue 11 (November 2019)

• Record Type: Journal Article
• Authors: Andjelkovic, Anuska V.; Xiang, Jianming; Stamatovic, Svetlana M.; Hua, Ya; Xi, Guohua; Wang, Michael M.; Keep, Richard F.
• Is Part Of: Arteriosclerosis, thrombosis, and vascular biology. Volume 39:Issue 11(2019)
• Publication Date: 2019-11
• Subjects: blood-brain barrier -- permeability -- reperfusion -- tight junctions -- transcytosis; Arteriosclerosis -- Periodicals; Thrombosis -- Periodicals; Blood-vessels -- Pathophysiology -- Periodicals; Electronic journals; 616.13
• DOI: 10.1161/ATVBAHA.119.312816
• Languages: English
• ISSNs: 1079-5642

Abstract

Abstract : Cerebral ischemia (stroke) induces injury to the cerebral endothelium that may contribute to parenchymal injury and worsen outcome. This review focuses on current preclinical studies examining how to prevent ischemia-induced endothelial dysfunction. It particularly focuses on targets at the endothelium itself. Those include endothelial tight junctions, transcytosis, endothelial cell death, and adhesion molecule expression. It also examines how such studies are being translated to the clinic, especially as adjunct therapies for preventing intracerebral hemorrhage during reperfusion of the ischemic brain. Identification of endothelial targets may prove valuable in a search for combination therapies that would specifically protect different cell types in ischemia.