Herquline A, produced by Penicillium herquei FKI-7215, exhibits anti-influenza virus properties. Issue 1 (2nd January 2017)

• Record Type: Journal Article
• Authors: Chiba, Takuya; Asami, Yukihiro; Suga, Takuya; Watanabe, Yoshihiro; Nagai, Takayuki; Momose, Fumitaka; Nonaka, Kenichi; Iwatsuki, Masato; Yamada, Haruki; Ōmura, Satoshi; Shiomi, Kazuro
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 81:Issue 1(2017)
• Page Start: 59
• Page End: 62
• Publication Date: 2017-01-02
• Subjects: herquline A -- influenza virus -- A/PR/8/34 strain -- Penicillium herquei; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2016.1162084
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: In the course of screening for new anti-influenza virus antibiotics, we isolated herquline A from a culture broth of the fungus, Penicillium herquei FKI-7215. Herquline A inhibited replication of influenza virus A/PR/8/34 strain in a dose-dependent manner without exhibiting cytotoxicity against several human cell lines. It did not inhibit the viral neuraminidase.