Lignans from Opuntia ficus-indica seeds protect rat primary hepatocytes and HepG2 cells against ethanol-induced oxidative stress. Issue 1 (2nd January 2017)

• Record Type: Journal Article
• Authors: Kim, Jung Wha; Yang, Heejung; Kim, Hyeon Woo; Kim, Hong Pyo; Sung, Sang Hyun
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 81:Issue 1(2017)
• Page Start: 181
• Page End: 183
• Publication Date: 2017-01-02
• Subjects: Opuntia ficus-indica -- lignin -- hepatoprotective activity -- heme oxygenase-1; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2016.1234930
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: Bioactivity-guided isolation of Opuntia ficus - indica (Cactaceae) seeds against ethanol-treated primary rat hepatocytes yielded six lignan compounds. Among the isolates, furofuran lignans 4 −6, significantly protected rat hepatocytes against ethanol-induced oxidative stress by reducing intracellular reactive oxygen species levels, preserving antioxidative defense enzyme activities, and maintaining the glutathione content. Moreover, 4 dose-dependently induced the heme oxygenase-1 expression in HepG2 cells.