Model systems for the study of human norovirus biology. (July 2009)

• Record Type: Journal Article
• Authors: Vashist, Surender; Bailey, Dalan; Putics, Akos; Goodfellow, Ian
• Is Part Of: Future virology. Volume 4:Number 4(2009)
• Page Start: 353
• Page End: 367
• Publication Date: 2009-07
• Subjects: animal models -- antiviral -- calicivirus -- gastroenteritis -- Norwalk virus -- PPMO -- ribavirin; Virology -- Periodicals; Virus diseases -- Treatment -- Periodicals; 616.9101
• DOI: 10.2217/fvl.09.18
• Languages: English
• ISSNs: 1746-0794

Abstract

The relative contribution of noroviruses to disease burden on society has only recently been established and they are now established as a major cause of gastroenteritis in the developed world. However, despite the medical relevance of these viruses, an efficient in vitro cell-culture system for human noroviruses has yet to be developed. As a result, much of our knowledge regarding the basic mechanisms of norovirus biology has come from studies using other members of the Caliciviridae family of small positive-stranded RNA viruses. Here, we aim to summarize the recent advances in the field, highlighting how model systems have played a key role in increasing our knowledge of this prevalent pathogen.