Yvh1 protein phosphatase is required for pre-autophagosomal structure formation after TORC1 inactivation. Issue 12 (2nd December 2015)

• Record Type: Journal Article
• Authors: Yeasmin, Akter M S T; Waliullah, Talukdar Muhammad; Kondo, Akihiro; Ushimaru, Takashi
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 79:Issue 12(2015)
• Page Start: 2022
• Page End: 2025
• Publication Date: 2015-12-02
• Subjects: autophagy -- pre-autophagosomal structure (PAS) -- Saccharomyces cerevisiae -- target of rapamycin complex 1 (TORC1) -- Yvh1; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2015.1060846
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: The pre-autophagosomal structure (PAS) is a putative site for autophagosome formation in budding yeast. Upon nutrient depletion or rapamycin treatment, target of rapamycin complex 1 (TORC1) becomes inactive, inducing PAS formation and autophagy. Here, we show that Yvh1 phosphatase is critical for PAS formation, but not autophagy induction, after TORC1 inactivation.