Catch and release of concanavalin A by a mannose-immobilized photoaffinity PEGA resin coupled with a cleavable disulfide linker. Issue 12 (2nd December 2015) - Kuramochi, Kouji
Abstract: A photoaffinity PEGA resin containing mannose as a ligand and disulfide as a cleavable linker was prepared. The resin was crosslinked to concanavalin A, a binding protein of mannose, by UV irradiation, and the protein was subsequently released by cleavage of the disulfide linker. Graphical abstract: : This work reports the design, synthesis and evaluation of an affinity resin to catch and release the target protein of a specific ligand