Convergent synthesis of 4, 5-branched inner-core oligosaccharides of lipopoly- and lipooligosaccharides. Issue 12 (2nd December 2015)

• Record Type: Journal Article
• Authors: Yi, Ruiqin; Narimoto, Hirofumi; Nozoe, Miku; Ichiyanagi, Tsuyoshi
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 79:Issue 12(2015)
• Page Start: 1931
• Page End: 1945
• Publication Date: 2015-12-02
• Subjects: glycosylation -- oligosaccharide -- heptose -- lipopolysaccharide -- lipooligosaccharide; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2015.1069698
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: The convergent synthesis of branched inner-core oligosaccharides of lipopoly- and lipooligosaccharide with a 3-deoxy-d - manno -oct-2-ulosonic acid (Kdo) disaccharide acceptor was achieved. The l - glycero -d - manno -heptopyranose (Hep) units for the branched core oligosaccharide Galβ(1-4)Glcβ(1-4)Hep and Hepα(1-3)Hep were prepared from the corresponding Hep building blocks. To obtain 4, 5-branched core oligosaccharide structures, the common acceptor Kdoα(2-4)Kdo was glycosylated with the Hep units. Graphical abstract: : Convergent synthesis of branched inner-core oligosaccharides of LPS/LOS.