Resveratrol derivative-rich melinjo (Gnetum gnemon L.) seed extract improves obesity and survival of C57BL/6 mice fed a high-fat diet. Issue 12 (2nd December 2015)

• Record Type: Journal Article
• Authors: Ikuta, Tomoki; Saito, Shinichiro; Tani, Hiroko; Tatefuji, Tomoki; Hashimoto, Ken
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 79:Issue 12(2015)
• Page Start: 2044
• Page End: 2049
• Publication Date: 2015-12-02
• Subjects: melinjo seed extract -- resveratrol derivatives -- obesity -- longevity -- high-fat diet-fed mice; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2015.1056510
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: Melinjo ( Gnetum gnemon L.) seed extracts (MSEs) are rich in resveratrol dimers (gnemonoside A, C, D, gnetin C), trans -resveratrol, and other resveratrol derivatives. trans -Resveratrol is a widely studied caloric restriction mimetic. In mice fed a high-fat diet (HFD), trans -resveratrol protects against obesity, type 2 diabetes, and premature death. Here, treatment of HFD-fed mice with 2.0% MSE significantly reduced body weight gain ( p < 0.001), blood insulin ( p < 0.01), and HOMA-IR ( p < 0.05) after 8 weeks compared with untreated HFD-fed mice. Additionally, 0.2% MSE treatment of HFD-fed mice significantly improved physiological activity ( p < 0.05) at 18 months of age and reduced risk of death due to HFD by 25% (hazard ratio = 0.75, p = 0.036). These data show that MSE can improve several aspects of metabolic syndrome and survival in mice and may have health benefits as a dietary supplement. Graphical abstract: : Resveratrol derivative-rich melinjo ( Gnetum gnemon L.) seed extract improves survival of C57BL/6 mice fed a high-fat diet.