Copper‐Catalyzed C3−H Difluoroacetylation of Quinoxalinones with Ethyl Bromodifluoroacetate. Issue 10 (4th April 2019)

• Record Type: Journal Article
• Authors: Wang, Liping; Liu, Hongyun; Li, Fanfan; Zhao, Jiquan; Zhang, Hong‐Yu; Zhang, Yuecheng
• Is Part Of: Advanced synthesis & catalysis. Volume 361:Issue 10(2019)
• Page Start: 2354
• Page End: 2359
• Publication Date: 2019-04-04
• Subjects: C−H difluoroacetylation -- Quinoxalin-2(1H)-ones -- Copper-Catalyzed -- Ethyl bromodifluoroacetate; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201900066
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A copper‐catalyzed direct C−H difluoroacetylation of quinoxalinones at the C‐3 position with ethyl bromodifluoroacetate has been developed. In this reaction, diverse difluoroacetylated quinoxalin‐2(1 H )‐ones with a wide range of functional groups could be obtained in moderate to good yields, using cheap, commercially available reagents. This protocol would offer a meaningfully synthetic method for pharmacologically interesting difluoroacetylated quinoxalin‐2(1 H )‐one derivatives. Abstract :