Blood glucose regulation and control of insulin and glucagon infusion using single model predictive control for type 1 diabetes mellitus. Issue 3 (1st June 2020)

• Record Type: Journal Article
• Authors: Crecil Dias, Cifha; Kamath, Surekha; Vidyasagar, Sudha
• Is Part Of: IET systems biology. Volume 14:Issue 3(2020)
• Page Start: 133
• Page End: 146
• Publication Date: 2020-06-01
• Subjects: predictive control -- blood -- medical control systems -- sugar -- diseases -- artificial organs -- patient treatment -- physiological models -- biochemistry; blood glucose -- longer control time -- insulin -- single model predictive controller -- glucagon infusion -- single model predictive control -- type 1 diabetes mellitus -- model predictive control algorithm -- comprehensive physiological model -- Sorensen model; Systems biology -- Periodicals; Cell physiology -- Periodicals; Biological systems -- Mathematical models -- Periodicals; Genetics -- Mathematical models -- Periodicals; Computational biology -- Periodicals; 573
• DOI: 10.1049/iet-syb.2019.0101
• Languages: English
• ISSNs: 1751-8849

Abstract

Abstract : This study elaborates on the design of artificial pancreas using model predictive control algorithm for a comprehensive physiological model such as the Sorensen model, which regulates the blood glucose and can have a longer control time in normal glycaemic region. The main objective of the proposed algorithm is to eliminate the risk of hyper and hypoglycaemia and have a precise infusion of hormones: insulin and glucagon. A single model predictive controller is developed to control the bihormones, insulin, and glucagon for such a development unmeasured disturbance is considered for a random time. The simulation result for the proposed algorithm performed good regulation lowering the hypoglycaemia risk and maintaining the glucose level within the normal glycaemic range. To validate the performance of the tracking of output and setpoint, average tracking error is used and 4.4 mg/dl results are obtained while compared with standard value (14.3 mg/dl).