Steps towards numerical verification of the terahertz in‐line measurement of tablet mixing by means of discrete element modelling. Issue 11 (13th August 2018)

• Record Type: Journal Article
• Authors: Lin, Hungyen; Pei, Chunlei; Markl, Daniel; Shen, Yaochun; Elliott, James A.; Zeitler, J. Axel
• Is Part Of: IET microwaves, antennas & propagation. Volume 12:Issue 11(2018)
• Page Start: 1775
• Page End: 1779
• Publication Date: 2018-08-13
• Subjects: pharmaceuticals -- coatings -- pharmaceutical industry -- ray tracing -- mixing -- discrete element method; numerical verification -- tablet mixing -- discrete element modelling -- terahertz in‐line sensing -- film coating thickness -- individual pharmaceutical tablets -- measurement analysis -- cumulative measurements -- discrete modelling -- tablet pan coater -- artificial lab‐scale tablet -- terahertz in‐line measurement modality -- off‐line measurements -- in‐line measurements -- coating process; Microwaves -- Periodicals; Microwave antennas -- Periodicals; Antennas (Electronics) -- Periodicals; Radio wave propagation -- Periodicals; Microwave communication systems -- Periodicals; 621.381305
• DOI: 10.1049/iet-map.2018.5561
• Languages: English
• ISSNs: 1751-8725

Abstract

Abstract : In recent years, terahertz in‐line sensing has been used to monitor the film coating thickness of individual pharmaceutical tablets during the coating process. In the previous work, the in‐line measurements were verified against off‐line measurements of samples from the same population. Here, we report on our recent progress to further verify the validity of the terahertz in‐line measurement modality using discrete element modelling for an artificial lab‐scale tablet mixing process inside a tablet pan coater. By coupling discrete modelling with a ray‐tracing method, it is then possible to estimate the cumulative measurements taken, which in turn can guide towards the fine‐tuning of the selection criteria as part of measurement analysis.