Conceptual basis and methodology of the SOPHIA study. (November 2007)
- Record Type:
- Journal Article
- Title:
- Conceptual basis and methodology of the SOPHIA study. (November 2007)
- Main Title:
- Conceptual basis and methodology of the SOPHIA study
- Authors:
- Glorioso, N
Argiolas, G
Filigheddu, F
Troffa, C
Cocco, F
Bulla, E
Bulla, P
Zaninello, R
Degortes, S
Pitzoi, S
Frau, F
Fadda, S
Pinna Parpaglia, P
Bernini, G
Bardini, M
Fallo, F
Malatino, L
Regolisti, G
Ferri, C
Cusi, D
Sciacqua, A
Perticone, F
Degli Esposti, E
Baraccani, C
Parati, G
Veglio, F
Mulatero, P
Williams, T A
Macciardi, F
Stancanelli, B - Abstract:
- To clarify the role of gene polymorphisms on the effect of losartan and losartan plus hydrochlorothiazide on blood pressure (primary end point) and on cardiac, vascular and metabolic phenotypes (secondary end point) after 4, 8, 12, 16 and 48 weeks treatment, an Italian collaborative study –– The Study of the Pharmacogenomics in Italian hypertensive patients treated with the Angiotensin receptor blocker losartan (SOPHIA) –– on never-treated essential hypertensives (n = 800) was planned. After an 8 week run-in, losartan 50 mg once daily will be given and doubled to 100 mg at week +4 if blood pressure is more than 140/90 mmHg. Hydroclorothiazide 25 mg once daily at week +8 and amlodipine 5 mg at week +16 will be added if blood pressure is more than 140/90 mmHg. Cardiac mass (echocardiography), carotid intima-media thickness, 24 h ambulatory blood pressure, homeostatic model assessment (HOMA) index, microalbuminuria, plasma renin activity and aldosterone, endogenous lithium clearance, brain natriuretic peptide and losartan metabolites will be evaluated. Genes of the renin––angiotensin––aldosterone system, salt sensitivity, the ββ-adrenergic system and losartan metabolism will be studied (Illumina custom arrays). A whole-genome scan will also be performed in half of the study cohort (1M array, Illumina 500 GX beadstation).
- Is Part Of:
- Pharmacogenomics. Volume 8:Number 11(2007)
- Journal:
- Pharmacogenomics
- Issue:
- Volume 8:Number 11(2007)
- Issue Display:
- Volume 8, Issue 11 (2007)
- Year:
- 2007
- Volume:
- 8
- Issue:
- 11
- Issue Sort Value:
- 2007-0008-0011-0000
- Page Start:
- 1497
- Page End:
- 1509
- Publication Date:
- 2007-11
- Subjects:
- drug therapy -- gene polymorphisms -- high blood pressure -- pharmacogenomics -- renin angiotensin system -- whole-genome scan
Pharmacogenomics -- Periodicals
615.1 - Journal URLs:
- http://www.futuremedicine.com/loi/pgs ↗
http://www.futuremedicine.com/ ↗ - DOI:
- 10.2217/14622416.8.11.1497 ↗
- Languages:
- English
- ISSNs:
- 1462-2416
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6446.249500
British Library DSC - BLDSS-3PM
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