Small inhibitory RNA –– a tool for credentialing candidate genes. (April 2005)

• Record Type: Journal Article
• Authors: Walgren, Richard A; McLeod, Howard L
• Is Part Of: Pharmacogenomics. Volume 6:Number 3(2005)
• Page Start: 281
• Page End: 292
• Publication Date: 2005-04
• Subjects: 6-thioguanine -- candidate genes -- cisplatin -- doxorubicin -- drug pathway -- hydroxyurea -- irinotecan -- pharmacogenetics -- siRNA -- taxol; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.1517/14622416.6.3.281
• Languages: English
• ISSNs: 1462-2416

Abstract

The effect of a drug is related to the interaction of the numerous gene products that participate in a drug pathway. The clinical importance of genetic variability on the overall outcome of most drug pathways remains to be determined. As a result, there is a need to efficiently identify the genes that not only participate in the pathway but also play a significant role in regulating the effects of a drug. The emerging technique of specific gene silencing through RNA interference initiated by small inhibitory RNA may prove to be a useful and powerful tool in the credentialing of candidate genes in drug pathways.