Clofarabine for the treatment of adult acute myeloid leukemia. (October 2009)

• Record Type: Journal Article
• Authors: Thomas, Xavier; Raffoux, Emmanuel; Elhamri, Mohamed; Lobe, Ida; Cannas, Giovanna; Dombret, Hervéé
• Is Part Of: Future oncology. Volume 5:Number 8(2009)
• Page Start: 1197
• Page End: 1210
• Publication Date: 2009-10
• Subjects: acute myeloid leukemia -- clofarabine -- new agents -- nucleoside analogs -- prognosis; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon.09.105
• Languages: English
• ISSNs: 1479-6694

Abstract

Clofarabine, a next-generation deoxyadenosine analog, has demonstrated significant activity in patients with acute myeloid leukemia (AML). The single-agent activity compares favorably with that demonstrated by the current standard antileukemia agents. Clofarabine has been safely and effectively combined with other agents and will probably become an integral part of induction and/or consolidation regimens in AML. Current studies are underway to better define the role of clofarabine in younger and elderly patients with AML, and also explore development strategies for an oral formulation.