Highly ordered graphene-isolated silver nanodot arrays as SERS substrate for detection of urinary nucleosides. (19th October 2015)

• Record Type: Journal Article
• Authors: Xu, Shicai; Jiang, Shouzhen; Hu, Guodong; Wei, Jie; Wang, Li; Zhang, Junye; Li, Qiuju
• Is Part Of: Laser physics. Volume 25:Number 11(2015:Nov.)
• Publication Date: 2015-10-19
• Subjects: graphene -- Ag nanodot arrays -- laser -- SERS -- urinary nucleosides; Lasers -- Periodicals; 621.36605
• DOI: 10.1088/1054-660X/25/11/115601
• Languages: English
• ISSNs: 1054-660X

Abstract

Abstract: An efficient surface enhanced Raman scattering (SERS) substrate has been developed based on highly ordered arrays of graphene-isolated Ag nanodot (G/AgND) arrays. By combining the plasmonic activity of AgND arrays and unique physical/chemical properties of graphene, the G/AgND arrays show high performance in terms of sensitivity, signal-to-noise ratio and reproducibility. The SERS signals of R6G are clearly detected even at very low concentration of 10 −11 M. The maximum deviations of SERS intensities from 20 positions of the SERS substrate are less than 5%. The G/AgND arrays were employed for detection of human urinary nucleosides. The diagnostic algorithms based on principal component analysis achieved a diagnostic sensitivity of 91.1% and specificity of 93.3% for separating cancer from normal samples. This work demonstrates that G/AgND arrays used in Raman spectroscopy could be developed as a smart and promising system for detection and screening of cancers.