Co‐Catalyzed Intramolecular S‐N Bond Formation in Water for 1, 2‐Benzisothiazol‐3(2H)‐ones and 1, 2, 4‐Thiadiazoles Synthesis. Issue 6 (7th January 2019)

• Record Type: Journal Article
• Authors: Yang, Liting; Song, Lijuan; Tang, Shanyu; Li, Longjia; Li, Heng; Yuan, Bingxin; Yang, Guanyu
• Is Part Of: European journal of organic chemistry. Issue 6(2019)
• Page Start: 1281
• Page End: 1285
• Publication Date: 2019-01-07
• Subjects: Benzisothiazol‐3(2H)‐one -- 1, 2, 4‐Thiadiazole -- Aqueous reaction -- Homogeneous catalysis -- Oxidation -- Radical reactions; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201801642
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : An efficient and versatile Co‐catalyzed intramolecular S‐N bond formation in water to synthesize 1, 2‐benzisothiazol‐3( 2H )‐one and 1, 2, 4‐thiadiazoles derivatives in good to excellent yields was developed. The transformation showed great tolerance with a broad range of substituents. The mother liquor was able to be recycled 6 times with minor loss in product yield. Abstract : Sustainable synthesis of 1, 2‐benzisothiazol‐3( 2H )‐ones and 1, 2, 4‐thiadiazoles via intramolecular S‐N bond formation were realized in aqueous media with good to excellent yields, which used tetra‐sulfonated cobalt phthalocyanine as a catalyst and molecular oxygen as the environment friendly oxidant.