Host factor reveals the intrinsic enzymatic activity of a bacterial effector. (December 2008)

• Record Type: Journal Article
• Authors: Auweter, Sigrid D; Bhavsar, Amit P; Finlay, B Brett
• Is Part Of: Future microbiology. Volume 3:Number 6(2008)
• Page Start: 617
• Page End: 620
• Publication Date: 2008-12
• Subjects: Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/17460913.3.6.617
• Languages: English
• ISSNs: 1746-0913

Abstract

Evaluation of: Lossi NS, Rolhion N, Magee AI, Boyle C, Holden DW: The Salmonella SPI-2 effector SseJ exhibits eukaryotic activator-dependent phospholipase A and glycerophospholipid:cholesterol acyltransferase activity. Microbiology 154, 2680––2688 (2008). The integral role that pathogenic bacterial effectors play during infection is well accepted; however, the biochemical activities of many pathogenic bacterial effectors remain unknown. Complicating the matter is the interplay between the bacterial effector and the host-cell environment. By way of example Lossi et al. demonstrate that recombinant SseJ is catalytically inactive in vitro but can be activated by a eukaryotic proteinaceous factor that remains to be identified and characterized.