Mind the nick. Issue 1 (2nd January 2019)

• Record Type: Journal Article
• Authors: Wellinger, Ralf Erik
• Is Part Of: Cell cycle. Volume 18:Issue 1(2019)
• Page Start: 115
• Page End: 117
• Publication Date: 2019-01-02
• Subjects: DNA nick -- R-loop -- DNA replication; Cell cycle -- Periodicals; 571.84377
• DOI: 10.1080/15384101.2018.1558861
• Languages: English
• ISSNs: 1538-4101

Abstract

ABSTRACT: Genomic DNA can be prone to endogenous nicks. The contribution of DNA nicks to genome instability includes the breakage of double-stranded DNA due to single-stranded DNA nicking. A recent study mapped the genome-wide distribution of endogenous DNA nicks suggesting that transcription contributes to the formation and distribution of DNA nicks. R-loops are a byproduct of transcription, and nicked DNA seems to contribute to R-loop formation and vice versa. Here, I want discuss the possibility that the 3ʹOH of nicked DNA at R-loops could trigger unscheduled replication events.