Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study. (June 2017)

• Record Type: Journal Article
• Authors: Hennebelle, Marie; Otoki, Yurika; Yang, Jun; Hammock, Bruce D.; Levitt, Anthony J.; Taha, Ameer Y.; Swardfager, Walter
• Is Part Of: Psychiatry research. Volume 252(2017)
• Page Start: 94
• Page End: 101
• Publication Date: 2017-06
• Subjects: AA arachidonic acid -- α-LNA α-linolenic acid -- BDI-II Beck Depression Inventory II -- BHT butylated hydroxytoluene -- COX cycolooxygenase -- CYP cytochrome p450 -- DHA docosahexaenoic acid -- DSM-V Diagnostic and Statistical Manual of Mental Disorders version V -- EDTA ethylenediaminetetraacetic acid -- EPA eicosapentaenoic acid -- LC-MS/MS liquid chromatography mass spectrometry -- LOQ imit of quantification -- LOX lipoxygenase -- MDD major depressive disorder -- MDD-s major depressive disorder with seasonal pattern -- PUFA polyunsaturated fatty acids -- she soluble epoxide hydrolase -- TPP triphinylphosphine -- UPLC-MS/MS ultra performance liquid chromatography; Oxylipins -- Fatty acids -- Seasonal major depression -- Depression -- Soluble epoxide hydrolase -- Omega-3 -- Omega-6 -- Cytochrome p450 -- Lipidomics; Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2017.02.056
• Languages: English
• ISSNs: 0165-1781

Abstract

Abstract: Many cytochrome p450-derived lipids promote resolution of inflammation, in contrast to their soluble epoxide hydrolase(sEH)-derived oxylipin breakdown products. Here we compare plasma oxylipins and precursor fatty acids between seasons in participants with major depressive disorder with seasonal pattern (MDD-s). Euthymic participants with a history of MDD-s recruited in summer-fall were followed-up in winter. At both visits, a structured clinical interview (DSM-5 criteria) and the Beck Depression Inventory II (BDI-II) were administered. Unesterified and total oxylipin pools were assayed by liquid chromatography tandem mass-spectrometry (LC-MS/MS). Precursor fatty acids were measured by gas chromatography. In nine unmedicated participants euthymic at baseline who met depression criteria in winter, BDI-II scores increased from 4.9±4.4 to 19.9±7.7. Four sEH-derived oxylipins increased in winter compared to summer-fall with moderate to large effect sizes. An auto-oxidation product (unesterified epoxyketooctadecadienoic acid) and lipoxygenase-derived 13-hydroxyoctadecadienoic acid also increased in winter. The cytochrome p450-derived 20-COOH-leukotriene B4 (unesterified) and total 14(15)-epoxyeicosatetraenoic acid, and the sEH-derived 14, 15-dihydroxyeicostrienoic acid (unesterified), decreased in winter. We conclude that winter depression was associated with changes in cytochrome p450- and sEH-derived oxylipins, suggesting that seasonal shifts in omega-6 and omega-3 fatty acid metabolism mediated by sEH may underlie inflammatory states in symptomatic MDD-s. Highlights: Oxylipins are lipids that reflect regulation of inflammatory and resolution pathways. Soluble epoxide hydrolase (sEH) produces oxylipins that are less anti-inflammatory. sEH derived oxylipins fluctuated between mood states in seasonal depression. sEH activity may underlie inflammatory states in symptomatic seasonal depression. This lipidomic assay offers new potential for standardized quantitative biomarkers.