Association of Y-linked variants with impulsivity and aggression in boys with attention-deficit/hyperactivity disorder of Chinese Han descent. (June 2017)

• Record Type: Journal Article
• Authors: Liu, Lu; Cheng, Jia; Li, Haimei; Su, Yi; Sun, Li; Yang, Li; Qian, Qiujin; Wang, Yufeng
• Is Part Of: Psychiatry research. Volume 252(2017)
• Page Start: 185
• Page End: 187
• Publication Date: 2017-06
• Subjects: ADHD -- Y-linked variants -- Externalizing behavior; Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2017.02.055
• Languages: English
• ISSNs: 0165-1781

Abstract

Abstract: Y chromosome plays important role in brain function and may help to explain the sex difference in attention-deficit/hyperactivity disorder (ADHD). A total of 857 boys with ADHD and 574 male controls were genotyped for 14 Y-linked markers. Analyses for both dichotomous phenotype and quantitative traits and the interaction effects with MAOA were performed. The results indicated significant association of four markers (M88, M95, M175, and M119) with inhibition function and aggression in boys with ADHD. Positive interaction effects with MAOA were also detected. In conclusion, some Y-linked variants may be associated with the impulsivity and aggression in boys with ADHD. Highlights: Y chromosome plays important role in brain function. We explored the association of 14 Y-linked variants with ADHD and the prominent externalizing behaviors in males. Four markers and their positive interaction with MAOA showed association with inhibition and aggression in boys with ADHD. Some Y-linked genetic variants may be involved in the etiology of ADHD and may help to explain the sex differences.