Single-center long-term results of vagus nerve stimulation for epilepsy: A 10–17 year follow-up study. (July 2018)

• Record Type: Journal Article
• Authors: Chrastina, Jan; Novák, Zdeněk; Zeman, Tomáš; Kočvarová, Jitka; Pail, Martin; Doležalová, Irena; Jarkovský, Jiří; Brázdil, Milan
• Is Part Of: Seizure. Volume 59(2018)
• Page Start: 41
• Page End: 47
• Publication Date: 2018-07
• Subjects: FDA food and drug administration -- VNS vagus nerve stimulation -- ILAE international league against epilepsy -- MRI magnetic resonance imaging -- NR non-responder -- R responder -- 90R 90% responder -- DBS deep brain stimulation; Epilepsy -- Vagus nerve stimulation -- Long term follow up -- Responder -- Battery replacement; Epilepsy -- Periodicals; Epilepsy -- Periodicals; Seizures -- Periodicals; Épilepsie -- Périodiques; Electronic journals; Electronic journals; 616.853
• DOI: 10.1016/j.seizure.2018.04.022
• Languages: English
• ISSNs: 1059-1311

Abstract

Highlights: The paper provides a long-term follow-up study (10–17 years) of VNS for epilepsy. The period before evaluating VNS as ineffective should be prolonged to over two years. The positive results of VNS are stable in long-term follow-up care exceeding 10 years. Preceding changes in antiepileptic medication are found in most late responders. The need for battery or complete system replacement correlates with good VNS outcome. Abstract: Purpose: The paper presents a long-term follow-up study of VNS patients, analyzing seizure outcome, medication changes, and surgical problems. Method: 74 adults with VNS for 10 to 17 years were evaluated yearly as: non-responder – NR (seizure frequency reduction <50%), responder – R (reduction ≥ 50% and <90%), and 90% responder – 90R (reduction ≥ 90%). Delayed R or 90R (≥ 4 years after surgery), patients with antiepileptic medication changes and battery or complete system replacement were identified. Statistical analysis of potential outcome predictors (age, seizure duration, MRI, seizure type) was performed. Results: The rates of R and 90R related to the patients with outcome data available for the study years 1, 2, 10, and 17 were for R 38.4%, 51.4%, 63.6%, and 77.8%, and for 90R 1.4%, 5.6%, 15.1%, and 11.1%. The absolute numbers of R and 90R increased until years 2 and 6. Antiepileptic therapy was changed in 62 patients (87.9%). There were 11 delayed R and four delayed 90R, with medication changes in the majority. At least one battery replacement was performed in 51 patients (68.9%), 49 of whom R or 90R. VNS system was completely replaced in 7 patients (9.5%) and explanted in 7 NR (9.5%). No significant predictor of VNS outcome was found. Conclusions: After an initial increase, the rate of R and 90R remains stable in long-term follow-up. The changes of antiepileptic treatment in most patients potentially influence the outcome. Battery replacements or malfunctioning system exchange reflect the patient's satisfaction and correlate with good outcomes.