MiR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ. (13th March 2021)

• Record Type: Journal Article
• Authors: Wang, Xuehui; Yao, Zhilu; Fang, Lin
• Other Names: Li Sainan Academic Editor.
• Is Part Of: PPAR research. Volume 2021(2021)
• Publication Date: 2021-03-13
• Subjects: Peroxisomes -- Periodicals; Peroxisomal disorders -- Periodicals; 571.65505
• DOI: 10.1155/2021/6661828
• Languages: English
• ISSNs: 1687-4757

Abstract

Abstract : In this study, we found that miR-22-3p expression was decreased in breast cancer (BC) cell lines and tissues. Overexpression of miR-22-3p inhibited the proliferation and migration of BC cells in vitro and in vivo, while depletion of miR-22-3p exhibited the opposite effect. Importantly, miR-22-3p could directly target PGC1 β and finally regulate the PPAR γ pathway in BC. In conclusion, miR-22-3p/PGC1 β suppresses BC cell tumorigenesis via PPAR γ, which may become a potential biomarker and therapeutic target.