The search for biomarkers of immune restoration disease associated with Mycobacterium tuberculosis in HIV patients beginning antiretroviral therapy. (April 2011)

• Record Type: Journal Article
• Authors: Oliver, Benjamin G; Price, Patricia
• Is Part Of: Biomarkers in medicine. Volume 5:Number 2(2011)
• Page Start: 149
• Page End: 154
• Publication Date: 2011-04
• Subjects: antiretroviral therapy -- antiretroviral therapy-associated tuberculosis -- CCL2 -- CXCL10 -- HIV-1 -- IFN-γγ -- IL-18 -- immune restoration disease -- Mycobacterium tuberculosis -- tuberculosis-associated immune reconstitution inflammatory syndrome; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm.11.16
• Languages: English
• ISSNs: 1752-0363

Abstract

Immune restoration disease associated with Mycobacterium tuberculosis is a complication of antiretroviral therapy seen in a subset of HIV-1 patients soon after they commence antiretroviral therapy. It is characterized by a ''paradoxical'' worsening of treated tuberculosis or an ''unmasking'' of subclinical tuberculosis. As antiretroviral therapy becomes increasingly available in countries with a high prevalence of tuberculosis, this form of immune restoration disease will become more common. Here we summarize biomarkers that may illuminate immunopathogenesis and assist in diagnosis.