Neuropsychiatric implications of transient receptor potential vanilloid (TRPV) channels in the reward system. (December 2019)

• Record Type: Journal Article
• Authors: Singh, Raghunath; Bansal, Yashika; Parhar, Ishwar; Kuhad, Anurag; Soga, Tomoko
• Is Part Of: Neurochemistry international. Volume 131(2019)
• Publication Date: 2019-12
• Subjects: TRPV channels -- Addiction -- Food reward -- Opioids -- Alcohol -- Cannabinoids; NPDs neuropsychiatric disorders -- BPAD bipolar affective disorder -- OCD obsessive-compulsive disorder -- ASD autism spectrum disorder -- ADHD attention deficit-hyperactivity disorder -- PTSD posttraumatic stress disorder -- WHO World Health Organization -- TRP transient receptor potential -- ER endoplasmic reticulum -- IP3 inositol-1, 4, 5 triphosphate -- PLC phospholipase C -- TRPC classical/canonical TRP channels -- TRPV vanilloid or capsaicin-sensitive TRP channels -- TRPM melastatin TRP channels -- TRPP polycystin TRP channels -- TRPML mucolipins TRP channels -- TRPA ankyrin TRP channels -- CNS central nervous system -- NAc nucleus accumbens -- VTA ventral tegmental area -- PVN paraventricular nucleus -- ARC arcuate nucleus -- SON supraoptic nucleus -- ANS accessory neurosecretory nuclei -- SOR retrochiasmatic area of the SON -- GlyR glycine receptor -- LTD long-term depression -- LTP long-term potentiation -- CPZ capsazepine -- AA-5HT arachidonoyl serotonin -- vmPFC ventral medial prefrontal cortex -- CB1 cannabinoid receptor 1 -- PKC protein kinase C -- CaMKII calcium/calmodulin-dependent protein kinase II -- DA dopamine -- mGluR metabotropic glutamate receptor -- 2-AG 2-arachidonoyl-glycerol -- AC adenylate cyclase; Neurochemistry -- Periodicals; Neurochemistry -- Periodicals; Neurochimie -- Périodiques; Neurochemistry; Periodicals; 612.804205
• DOI: 10.1016/j.neuint.2019.104545
• Languages: English
• ISSNs: 0197-0186

Abstract

Abstract: Neuropsychiatric disorders (NPDs) exert a devastating impact on an individual's personal and social well-being, encompassing various conditions and brain anomalies that influence affect, cognition, and behavior. Because the pathophysiology of NPDs is multifactorial, the precise mechanisms underlying the development of such disorders remain unclear, representing a unique challenge in current neuropsychopharmacotherapy. Transient receptor potential vanilloid (TRPV) type channels are a family of ligand-gated ion channels that mainly include sensory receptors that respond to thermal, mechanical and chemical stimuli. TRPV channels are abundantly present in dopaminergic neurons, thus playing a pivotal role in the modulation of the reward system and in pathophysiology of diseases such as stress, anxiety, depression, schizophrenia, neurodegenerative disorders and substance abuse/addiction. Recent evidence has highlighted TRPV channels as potential targets for understanding modulation of the reward system and various forms of addiction (opioids, cocaine, amphetamines, alcohol, nicotine, cannabis). In this review, we discuss the distribution, physiological roles, ligands and therapeutic importance of TRPV channels with regard to NPDs and addiction biology. Highlights: Neuropsychiatric disorders (NPDs) and drug-abuse have a global socioeconomic burden. TRPV channels are distributed abundantly in CNS. TRPV channels are in involved in many forms of addiction and NPDs. TRPV modulation need to be explored for novel therapeutics in NPDs and addiction.